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修复药物或取代补牙材料实现牙质再生

成果名称 修复药物或取代补牙材料实现牙质再生
成果编号 1703 完成日期 Expression article.completeDate is undefined on line 46, column 3 in component://clii/webapp/clii/template/default/app/Cms/CmsTechnologyResult/CmsTechnologyResultDetail.ftl. The problematic instruction: ---------- ==> ${article.completeDate?string("yyyy")!} [on line 46, column 1 in component://clii/webapp/clii/template/default/app/Cms/CmsTechnologyResult/CmsTechnologyResultDetail.ftl] ---------- Java backtrace for programmers: ---------- freemarker.core.InvalidReferenceException: Expression article.completeDate is undefined on line 46, column 3 in component://clii/webapp/clii/template/default/app/Cms/CmsTechnologyResult/CmsTechnologyResultDetail.ftl. at freemarker.core.TemplateObject.assertNonNull(TemplateObject.java:125) at freemarker.core.TemplateObject.invalidTypeException(TemplateObject.java:135) at freemarker.core.BuiltIn$stringBI._getAsTemplateModel(BuiltIn.java:426) at freemarker.core.Expression.getAsTemplateModel(Expression.java:89) at freemarker.core.MethodCall._getAsTemplateModel(MethodCall.java:86) at freemarker.core.Expression.getAsTemplateModel(Expression.java:89) at freemarker.core.DefaultToExpression._getAsTemplateModel(DefaultToExpression.java:100) at freemarker.core.Expression.getAsTemplateModel(Expression.java:89) at freemarker.core.Expression.getStringValue(Expression.java:93) at freemarker.core.DollarVariable.accept(DollarVariable.java:76) at freemarker.core.Environment.visit(Environment.java:221) at freemarker.core.MixedContent.accept(MixedContent.java:92) at freemarker.core.Environment.visit(Environment.java:221) at freemarker.core.IfBlock.accept(IfBlock.java:82) at freemarker.core.Environment.visit(Environment.java:221) at freemarker.core.MixedContent.accept(MixedContent.java:92) at freemarker.core.Environment.visit(Environment.java:221) at freemarker.core.Environment.process(Environment.java:199) at org.ofbiz.base.util.template.FreeMarkerWorker.renderTemplate(FreeMarkerWorker.java:251) at org.ofbiz.widget.screen.HtmlWidget.renderHtmlTemplate(HtmlWidget.java:224) at org.ofbiz.widget.screen.HtmlWidget$HtmlTemplate.renderWidgetString(HtmlWidget.java:269) at org.ofbiz.widget.screen.HtmlWidget.renderWidgetString(HtmlWidget.java:129) at org.ofbiz.widget.screen.ModelScreenWidget$PlatformSpecific.renderWidgetString(ModelScreenWidget.java:988) at org.ofbiz.widget.screen.ModelScreenWidget.renderSubWidgetsString(ModelScreenWidget.java:102) at org.ofbiz.widget.screen.ModelScreenWidget$Section.renderWidgetString(ModelScreenWidget.java:189) at org.ofbiz.widget.screen.ModelScreenWidget.renderSubWidgetsString(ModelScreenWidget.java:102) at org.ofbiz.widget.screen.ModelScreenWidget$DecoratorSection.renderWidgetString(ModelScreenWidget.java:696) at org.ofbiz.widget.screen.ModelScreenWidget$SectionsRenderer.render(ModelScreenWidget.java:127) at org.ofbiz.widget.screen.ModelScreenWidget$DecoratorSectionInclude.renderWidgetString(ModelScreenWidget.java:729) at org.ofbiz.widget.screen.ModelScreenWidget.renderSubWidgetsString(ModelScreenWidget.java:102) at org.ofbiz.widget.screen.ModelScreenWidget$Section.renderWidgetString(ModelScreenWidget.java:189) at org.ofbiz.widget.screen.ModelScreenWidget.renderSubWidgetsString(ModelScreenWidget.java:102) at org.ofbiz.widget.screen.ModelScreenWidget$Section.renderWidgetString(ModelScreenWidget.java:189) at org.ofbiz.widget.screen.ModelScreen.renderScreenString(ModelScreen.java:396) at org.ofbiz.widget.screen.ScreenFactory.renderReferencedScreen(ScreenFactory.java:216) at org.ofbiz.widget.screen.ModelScreenWidget$DecoratorScreen.renderWidgetString(ModelScreenWidget.java:663) at org.ofbiz.widget.screen.ModelScreenWidget.renderSubWidgetsString(ModelScreenWidget.java:102) at org.ofbiz.widget.screen.ModelScreenWidget$Section.renderWidgetString(ModelScreenWidget.java:189) at org.ofbiz.widget.screen.ModelScreen.renderScreenString(ModelScreen.java:396) at org.ofbiz.widget.screen.ScreenRenderer.render(ScreenRenderer.java:135) at org.ofbiz.widget.screen.ScreenRenderer.render(ScreenRenderer.java:97) at org.ofbiz.widget.screen.MacroScreenViewHandler.render(MacroScreenViewHandler.java:111) at org.ofbiz.webapp.control.RequestHandler.renderView(RequestHandler.java:999) at org.ofbiz.webapp.control.RequestHandler.doRequest(RequestHandler.java:680) at org.ofbiz.webapp.control.ControlServlet.doGet(ControlServlet.java:219) at javax.servlet.http.HttpServlet.service(HttpServlet.java:621) at javax.servlet.http.HttpServlet.service(HttpServlet.java:722) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:305) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:210) at org.ofbiz.webapp.control.ContextFilter.doFilter(ContextFilter.java:314) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:243) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:210) at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:222) at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:123) at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:502) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:171) at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:100) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:118) at org.apache.catalina.valves.AccessLogValve.invoke(AccessLogValve.java:953) at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:408) at org.apache.coyote.http11.AbstractHttp11Processor.process(AbstractHttp11Processor.java:1041) at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:603) at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:310) at java.util.concurrent.ThreadPoolExecutor$Worker.runTask(ThreadPoolExecutor.java:886) at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:908) at java.lang.Thread.run(Thread.java:619)
完成单位 伦敦大学国王学院 科研人员 伦敦大学国王学院
成果简介   英国科研人员发现,一种有助牙髓再生的药物能让龋齿康复,若推广应用或许能取代补牙填充物,免除患者补牙之苦。   伦敦大学国王学院研究人员将生物可降解棉球浸满一种名为Tideglusib的药物,再将棉球置入小鼠龋齿蛀洞中,结果增强了牙髓干细胞活动,实现牙质再生。再生的牙质最终取代了降解的棉球,修复了直径0.13毫米的蛀洞。   研究结果发表于英国期刊《科学报告》。英国广播公司9日引用参与研究的保罗·夏普教授的话说,这种疗法的优势在于可以一劳永逸地治疗龋齿。   牙齿的再生能力相对较弱。一旦牙齿表层的牙釉质遭腐蚀,牙齿会自发形成一层薄薄的牙质保护牙髓,但对较大的龋齿则毫无办法。作为补救,牙医会用汞合金或树脂等复合材料填充蛀洞,修复龋齿。然而,随着填充材料的磨损,龋齿患者一生中往往要多次替换材料补牙。   夏普说,如果采用药物修复疗法,随着牙质再生,原本由可再生棉球占据的空间将充满矿物质,无需担心日后磨损。他甚至预言,这种实验疗法用不了多久就能得到推广应用。“这是再生医学垂手可得的果实,在3到5年内或许就能实现商业应用,”他说。
应用案例
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